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Living amphibian data: genome, experiment and tree

Compare one frog genome, receptor-knockout metamorphosis and a synthetic species timetree without treating extant datasets as fossils, ancestors or complete taxonomic coverage.

Each step names its evidence claims, with references below. Interactive Explorer states are available in the full application; the narrative remains an editorial synthesis.

Story sequence

01 · 0 Ma · evidence

One individual, one draft genome

The Xenopus tropicalis draft assembly is a powerful extant reference with an accession and known sampling boundary, not a genome for all amphibians.

Extant genomic comparison does not directly observe lineage origins.

claim:event:xenopus-tropicalis-draft-genome
02 · 0 Ma · evidence

Metamorphosis differs by receptor and organ

TRβ knockout delays tail regression while TRα knockout advances hindlimbs, making the experiment mechanistic but model- and tissue-specific.

Experimental causation in one laboratory model is not a universal amphibian rule.

claim:event:xenopus-thyroid-receptor-metamorphosis
03 · 0 Ma · tree

Molecular and taxonomic placements coexist

The 7,238-species posterior uses molecular data for 4,061 species and soft taxonomic inference for the rest; its times are model outputs.

COL26.8 naming coverage, sequence sampling and mature evidence dossiers remain different inventories.

claim:event:extant-amphibian-7238-species-timetree

References

  1. The genome of the Western clawed frog Xenopus tropicalisHellsten, U.; Harland, R.M.; Gilchrist, M.J.; et al. · 2010 · DOI 10.1126/science.1183670
  2. Thyroid hormone receptor α- and β-knockout Xenopus tropicalis tadpoles reveal subtype-specific roles during developmentNakajima, K.; Tazawa, I.; Yaoita, Y. · 2018 · DOI 10.1210/en.2017-00601
  3. The interplay of past diversification and evolutionary isolation with present imperilment across the amphibian tree of lifeJetz, W.; Pyron, R.A. · 2018 · DOI 10.1038/s41559-018-0515-5