Gastropod Nodal chirality experiment

Expression and inhibition experiments connect a conserved signalling pathway to opposite shell chirality in two snails.

Represented range0–0 Ma

RegionsLaboratory embryos of Lottia gigantea and Biomphalaria glabrata

CladesGastropoda · Lottia gigantea · Biomphalaria glabrata

Claim ledger

event-mechanism · high

In Lottia gigantea and Biomphalaria glabrata embryos, nodal and Pitx expression occurs on opposite sides corresponding to adult chirality, and Nodal-pathway inhibition disrupts Pitx expression and shell coiling in the sampled system.

claim:event:gastropod-nodal-chirality

References

Nodal signalling is involved in left–right asymmetry in snailsGrande, C.; Patel, N.H. · 2009 · DOI 10.1038/nature07603

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