A 16,397-base-pair dataset of 19 nuclear and 3 mitochondrial genes from 42 placentals and 2 marsupial outgroups recovered Afrotheria, Xenarthra, Laurasiatheria and Euarchontoglires and an Afrotheria-rooted topology under Bayesian and maximum-likelihood analyses; the root, approximately 103 Ma date and Gondwanan scenario remain model-conditioned.