References / paperThyroid hormone receptor α- and β-knockout Xenopus tropicalis tadpoles reveal subtype-specific roles during development
Nakajima, K.; Tazawa, I.; Yaoita, Y.
Year2018
Source roleprimary-study
DOI / ID10.1210/en.2017-00601
Fitness and scope
event-mechanism · morphology · methods
Controlled Xenopus tropicalis TRα- and TRβ-knockout comparison spanning external development, tail and intestine histology, and expression of extracellular-matrix-degrading genes.
Claim ledger
event-mechanism · highXenopus tropicalis knockout experiments separate thyroid-receptor subtype effects: TRβ loss delays tail regression and extracellular-matrix degradation, whereas TRα loss advances hindlimb development with a largely normal tail trajectory; the result is model- and organ-specific.
claim:event:xenopus-thyroid-receptor-metamorphosis